Association Between Metabolic Syndrome Components and Thyroid Hormone Profiles in Adults With Obesity
DOI:
https://doi.org/10.61336/jdme.0702.04Keywords:
Metabolic syndrome, obesity, thyroid hormones, TSH, FT3, FT4, insulin resistance, dyslipidemiaAbstract
Metabolic syndrome is characterized by a cluster of interrelated metabolic abnormalities that may be accompanied by alterations in thyroid hormone regulation. This study examined the relationship between individual metabolic syndrome components and thyroid hormone profiles in adults with obesity. A comparative cross-sectional study was conducted among 132 adults with obesity, including participants with fewer metabolic syndrome components and those meeting criteria for metabolic syndrome. Serum thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), and the FT3/FT4 ratio were measured. Metabolic parameters included waist circumference, blood pressure, fasting glucose, triglycerides, and HDL cholesterol. Participants with a greater number of metabolic syndrome components demonstrated higher TSH and lower FT4 concentrations. The FT3/FT4 ratio was higher among participants with greater metabolic burden. Among individual components, elevated triglycerides and impaired fasting glucose showed the strongest associations with thyroid hormone differences. These findings suggest that the accumulation and type of metabolic abnormalities may be associated with distinct thyroid hormone patterns in adults with obesity.
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