Adiposity Distribution and Early Renal Risk Markers in Patients With Type 2 Diabetes
DOI:
https://doi.org/10.61336/jdme.0601.05Keywords:
Type 2 diabetes, adiposity distribution, central obesity, renal risk, albuminuriaAbstract
The distribution of adipose tissue may influence renal risk among individuals with type 2 diabetes independently of overall body mass. This study evaluated the relationship between adiposity distribution and early renal risk markers in adults with type 2 diabetes. A cross-sectional observational study included 176 adults with established type 2 diabetes. Anthropometric measurements included body mass index, waist circumference, waist-to-hip ratio, and waist-to-height ratio. Renal assessment included urinary albumin-to-creatinine ratio, estimated glomerular filtration rate, and serum cystatin C. Glycemic and metabolic parameters were also assessed. Participants with greater central adiposity had higher urinary albumin-to-creatinine ratios and cystatin C concentrations and lower estimated glomerular filtration rates. Waist circumference and waist-to-height ratio demonstrated stronger associations with urinary albumin excretion than BMI. After adjustment for age, sex, diabetes duration, HbA1c, blood pressure, and BMI, waist-to-height ratio remained independently associated with urinary albumin-to-creatinine ratio. These findings suggest that central adiposity may be associated with early renal abnormalities in type 2 diabetes and that simple measures of fat distribution may provide additional information beyond BMI.
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